SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion
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منابع مشابه
Defecicient of ADAP/Fyb/SLAP130 destablize SKAP 55 in Jurkat T cells
JURKAT T CELLS Yanping Huang‡¶, Darrell D. Norton‡, Patricia Precht‡, Jennifer L. Martindale‡, Janis K Burkhardt§ and Ronald L. Wange‡ From the ‡Laboratory of Cellular and Molecular Biology, National Institute on Aging, IRP/NIH/DHHS, Baltimore, MD 21224, USA, and the §Department of Pathology, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 1910...
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While the adaptor SKAP-55 mediates LFA-1 adhesion on T-cells, it is not known whether the adaptor regulates other aspects of signaling. SKAP-55 could potentially act as a node to coordinate the modulation of adhesion with downstream signaling. In this regard, the GTPase p21(ras) and the extracellular signal-regulated kinase (ERK) pathway play central roles in T-cell function. In this study, we ...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2008
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2008.07.005